CEC-UW Publications

CEC-UW publications include:

1. Fiore MC, Smith SS, Adsit RT, Bolt DM, Conner KL et al. (2022) The First 20 Months of the Covid-19 Pandemic: Mortality, Intubation, and ICU Rates Among 104,590 Patients Hospitalized at 21 United States Health Systems. PLOS ONE. Online September 28, 2022.
   • Rates of death, intubation, and admission to intensive care improved markedly during the first 20 months of the pandemic among adults hospitalized with COVID-19.
   • News release
2. Nolan MB, Piasecki TM, Smith SS, Baker TB, Fiore MC et al. (2022) Relations of Current and Past Cancer with Severe Outcomes among 104,590 Hospitalized COVID-19 Patients: The COVID EHR Cohort at the University of Wisconsin. Cancer Epidemiology, Biomarkers & Prevention. EPI-22-0500. Online August 15, 2022.
   • A current cancer diagnosis posed a significant risk for severe outcomes (ICU admission and death) over the first two years of the COVID-19 pandemic. Prior COVID-19 vaccination significantly reduced the risk of death amongst cancer patients who develop COVID-19.
   • News release
3. Piasecki T, Smith SS, Baker TB, Slutske WS, Adsit RT et al. (2022) Smoking Status, Nicotine Medication, Vaccination, and COVID-19 Hospital Outcomes; Findings From the COVID EHR Cohort at the University of Wisconsin (CEC-UW) Study. Nicotine Tobacco Research. Online September 7, 2022.
   • Among current smokers hospitalized with COVID-19, prescriptions for nicotine patches, lozenges, or gum were associated with reduced mortality.
   • News release
4. Baker TB, Bolt DM, Smith SS, Piasecki TM, Conner KL et al. (2023) The Relationship of COVID-19 Vaccination with Mortality Among 86,732 Hospitalized Patients: Subpopulations, Patient Factors, and Changes Over Time. Journal of General Internal Medicine. Online January 18, 2023.
   • Having a COVID-19 vaccination reduces the likelihood of dying from COVID and the size of this effect differs across different patient groups. In particular, the benefits of vaccination are especially great for some of those who otherwise would have had the greatest risk of SARS-CoV-2 mortality.
   • News release
5. Nolan MB, Nolan ME, Piasecki TM, Fiore MC. (2023) Mortality by Age Group and Intubation Status in Adult Hospitalized Patients from 21 U.S. Hospital Systems during Three Surges of the COVID-19 Pandemic. CHEST. S0012-3692(23)00160-5. Online January 23, 2023.
   • Through three COVID-19 surges, these data illustrate the stepwise increase in overall mortality rates by age up to ≥90 years. Though intubated patients had differentially higher mortality rates during the delta wave, mortality rates among those patients who required intubation peaked among those aged 70 to 79 years during all three surges. If patients were sick enough to require mechanical ventilation, mortality rates were remarkably consistent regardless of vaccination status.
6. Baker TB, Loh WY, Piasecki TM, Bolt DM, Smith SS et al. A Machine Learning Analysis of Correlates of Mortality Among Patients Hospitalized with COVID-19. Scientific Reports. 13, 4080. Online March 11, 2023.
   • This research used machine learning strategies to explore the associations of demographic and comorbidity risk factors with mortality in a large sample of patients hospitalized with COVID-19. The 10 risk factors with the strongest overall associations with mortality, reflecting both their main and interactive effects, were age, uncomplicated hypertension, insurance status, site (health system), renal failure, diabetes, vaccination status (binary and number of immunizations), complicated hypertension, and sex.