University of Wisconsin–Madison

Bupropion

Bupropion bottles

Package insert

What is Bupropion?
Bupropion is a prescription drug and quit smoking aid with the name brands Zyban and Wellbutrin. It:

  • Does not have nicotine
  • Can reduce withdrawal symptoms, like anger, low mood, anxiety, and cravings
  • Is covered by health costs

How to Get Started
Talk with your doctor before using bupropion especially if any of these apply to you:

  • Pregnant or breastfeeding
  • Taking anything with bupropion or MAO inhibitors
  • Drinking a lot of alcohol or stopped drinking abruptly
  • Have a history of:
    • Seizure disorder or epilepsy
    • An eating disorder, like anorexia
    • Heart issues or high blood pressure

Dose and Schedule
Bupropion comes in 150 mg pills. Most doctors prescribe it for 7-12 weeks.

  • Start taking it 1-2 weeks before your quit date.
  • Take one pill each morning for 3 days.
  • After 3 days, take pill in the morning and one in the evening (at least 8 hours apart).
  • If you miss a dose, just skip it and continue with your regular dose schedule. Do not double dose.

Tips for Use

  • Do not chew, cut, or crush pills.
  • You may take the pill with or without food.
  • You can use bupropion and nicotine gum or patches at the same time, but this may make your blood pressure go up.
  • Be careful driving until you know how bupropion affects you.
  • If bupropion makes it hard for you to sleep, do not take it close to bedtime.
  • If you relapse, keep taking bupropion and get right back to quitting.

Side Effects
Common side effects include:

  • Stuffy nose
  • Dry mouth
  • Dizzy feeling
  • Anxiety
  • Nausea
  • Constipation
  • Joint aches
  • Trouble sleeping

Stop taking bupropion and call your doctor right away if you feel more agitated or depressed, or have suicidal thoughts during or after use.