The Guideline panel closely reviewed thousands of journal articles and selected the following primary topics to update in the 2008 edition:
1. Telephone quit lines
2. Combining counseling and medication relative to either counseling or medication
3. Varenicline
4. Medication combinations
5. Long-term effectiveness of medication
6. Smokers with low socio-economic status/limited formal education
7. Adolescent smokers
8. Pregnant smokers
9. Psychiatric illness and/or non-tobacco chemical dependencies
10. Providing cessation interventions as a health benefit
11. Systems interventions, including provider training and the combination of training and systems interventions