Options Study

Could Zyn help you address your smoking?

Can Zyn help you address your smoking?

Get up to $380 for completing the UW research study with occasional visits to find out.

Sign me up!

The UW School of Medicine and Public Health is currently recruiting participants for a study to see if nicotine pouches can replace smoking for study participants.

Nicotine pouches—microfiber sachets containing nicotine but no tobacco leaf—are a new class of oral tobacco products rapidly growing in popularity. Popular brands include On!, Velo and Zyn. Earlier this year, the FDA authorized the products for sale.

Sign up here

Ready? Click here! Or call 844-692-0500.

Be a part of it

Join a group of hundreds of people who also smoke in this study.

Who’s Eligible

  • If you’re 21+
  • Smoke
  • Don’t plan to quit smoking soon

Ready? Click here!

Or call 844-692-0500.

Four women who are friends

What you'll do

Two men fist-bump

Participants will be randomly assigned to one of four product conditions:

1) 3-mg nicotine pouches;
2) 6-mg nicotine pouches;
3) nicotine mini-lozenges (2- or 4-mg); or
4) no study product.

Participants receiving a study product (nicotine pouches or nicotine mini lozenges) will be asked to use them for four weeks, an initial experimentation week, and then for a three-week switching trial where they will be asked not to smoke their usual cigarettes and instructed instead to use their study product (if assigned one).

Before and after the switching trial, participants will come to the clinic following overnight abstinence and will use their assigned study product or a mint during a 30-minute sampling test to assess the duration of product use, subjective evaluations of study products, and suppression of craving and withdrawal symptoms under controlled conditions.

During the four weeks of the study, participants will use a phone app to record, in real-time, each time they use cigarettes or a study product. For a random daily subset of use events, participants will answer additional questions about the context of their use and potential reasons why (such as nicotine withdrawal or product satisfaction).

“It’s a question of public health,” said Co-Principal Investigator and UW-CTRI Researcher Dr. Thomas Piasecki. “If people can switch from cigarettes to nicotine pouches, that would likely be a win for public health.”

Sign up here

Sign up: Click here or call 844-692-0500.